Scarring and contraction in and around the eye are very important causes of visual morbidity, and play a part in the failure
of treatment for most major blinding diseases today. Examples include lens capsule contraction, proliferative vitreoretinopathy,
macular scarring, corneal scarring, glaucoma surgery, and eyelid and orbital contraction following disease.
The theme also includes diseases such as severe retinopathy of prematurity, for which there are no effective treatments and which
result in a lifetime of blindness. Many researchers and groups at Moorfields and the UCL Institue of Ophthalmology work on virtually
all of these conditions. Appropriate delivery and formulation systems will be developed through this theme.
We are focussing on developing new surgical techniques to improve surgery based on basic laboratory understanding of
biological responses; the role of growth factors and their effect on ocular scarring; the cellular and molecular basis of cell motility
(spontaneous movement) and scarring; and ocular stem cells – basic biology and therapeutic use including prevention of
scarring, tissue reconstruction and regeneration.